In Reply: Dr Clarke highlights the importance
of systematic reviews of RCTs for providing a reliable summary of the evidence
so that patients and physicians can make well-informed medical decisions.
High-quality systematic reviews efficiently integrate information and provide
data for rational decision making. They establish whether findings are consistent
and can be generalized or whether findings vary by subsets. Meta-analyses,
where appropriate, can increase power and precision to enhance estimates of
treatment effects and exposure risk.1
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