We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Efficacy of Glucosamine and Chondroitin for Treatment of Osteoarthritis—Reply

Timothy E. McAlindon, DM, MPH; Michael P. LaValley, PhD; David T. Felson, MD, MPH
JAMA. 2000;284(10):1241. doi:10.1001/jama.284.10.1239.
Text Size: A A A
Published online


In Reply: Dr Mautone expresses concern that we did not give credit to some trials for ITT analyses even when this was stated in the text of our article. In Reichelt's study, the ITT results for the primary outcome measure are not reported—the trials by Rovati and Bucsi gave no indication of an ITT approach. For the study by Bourgeois et al, we would like to acknowledge that this was indeed misclassified in the table in our article, as Mautone points out.

We also agree with Mautone that the support of the pharmaceutical industry is critical in advancing research in therapeutic compounds. Of course, this poses a dilemma in a meta-analysis because it has been shown repeatedly that industry involvement in clinical trials is more frequently associated with positive results.1,2 We also emphasize that we used quality evaluation in our analyses to help evaluate the overall weight of evidence for efficacy of these compounds. This critical component of meta-analytic methodology should not be viewed as an attempt to discredit individual trials or investigators, nor was this our intent.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.