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Serologic Testing for Lyme Disease

Martin E. Schriefer, PhD; David T. Dennis, MD, MPH; Duane J. Gubler, ScD; Edward B. Hayes, MD; Barbara J. B. Johnson, PhD; May C. Chu, PhD
JAMA. 2000;284(6):695-696. doi:10.1001/jama.284.6.691.
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To the Editor: We were surprised by the results presented by Dr Schutzer and colleagues1 reporting on an immune complex diagnostic method for Lyme disease; this method was first described by Schutzer et al almost 10 years ago.2 Our experience with the immune complex approach differs substantially from theirs.

In February 1999, Dr Schutzer and Dr Coyle participated in a blinded study (referred to as a pilot study in their article) with the Centers for Disease Control and Prevention (CDC), in which the immune complex approach was compared with the nationally recommended 2-tier serologic testing.3 The CDC provided 60 blinded and coded samples to each participating group: 25 samples from 13 patients with early, culture-confirmed Lyme disease, 25 samples from control subjects with no history of Lyme disease, and 5 repeated samples from each of these 2 sample groups.

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