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Circadian Relationship of Serum Uric Acid and Nitric Oxide

Eugene L. Kanabrocki, PhD; Jane L. H. C. Third, MD; May D. Ryan, RN, MS; Bernard A. Nemchausky, MD; Parvez Shirazi, MD; Lawrence E. Scheving, PhD; James B. McCormick, MD; Ramon C. Hermida, PhD; W. Fraser Bremner, MD, PhD; Debbie A. Hoppensteadt, PhD; Jawed Fareed, PhD; John H. Olwin, MD
JAMA. 2000;283(17):2240-2241. doi:10.1001/jama.283.17.2235.
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To the Editor: Nitric oxide–mediated damage has been implicated in a number of neurological diseases including stroke1,2 and multiple sclerosis (MS).3 For instance, monocytes expressing high levels of nitric oxide synthetase have been found in plaques from the brains of patients with MS.4 The proximal agent of neuronal cell damage may be peroxynitrite, which is formed in vivo from the synthesis of nitric oxide and superoxide.

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Figure. Comparison of Circadian Variation in Serum Nitric Oxide and Uric Acid
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P values were calculated from testing the 0 amplitude assumption. MESOR indicates the midline estimating statistic of rhythm; CI, confidence interval; amplitude, half the distance between the maximum and minimum of the fitted curve; orthophase, lag from a defined reference point of the crest time in the curve fitted to the data; and bathyphase, lag from the same reference point of the time of lowest value in the curve fitted to the data. The curve represented for each variable corresponds to the best fitted model obtained by population multiple-components analysis (with corresponding characteristics given in the table above). The arrows from the upper horizontal axis indicate the circadian orthophase for each variable. The shaded area on the timeline represents sleep.



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