To the Editor: Nitric oxide–mediated
damage has been implicated in a number of neurological diseases including
stroke1,2 and multiple
sclerosis (MS).3 For instance, monocytes
expressing high levels of nitric oxide synthetase have been found in plaques
from the brains of patients with MS.4 The
proximal agent of neuronal cell damage may be peroxynitrite, which is formed
in vivo from the synthesis of nitric oxide and superoxide.
P values were calculated from testing the
0 amplitude assumption. MESOR indicates the midline estimating statistic of
rhythm; CI, confidence interval; amplitude, half the distance between the
maximum and minimum of the fitted curve; orthophase, lag from a defined reference
point of the crest time in the curve fitted to the data; and bathyphase, lag
from the same reference point of the time of lowest value in the curve fitted
to the data. The curve represented for each variable corresponds to the best
fitted model obtained by population multiple-components analysis (with corresponding
characteristics given in the table above). The arrows from the upper horizontal
axis indicate the circadian orthophase for each variable. The shaded area
on the timeline represents sleep.
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