In Reply: Dr Vgontzas and colleagues have shown
that obese persons with sleep apnea have higher IL-6 concentrations than obese
persons without sleep apnea. Other studies making similar comparisons have
reported a relatively higher waist circumference and a greater amount of abdominal
visceral fat accumulation in obese persons with sleep apnea.1
Abdominal fat distribution was also associated with elevated CRP concentrations
in our study. There is still controversy about whether omental adipocytes
produce more IL-6 compared with subcutaneous adipocytes.2
Therefore, it would be of interest to determine whether the difference in
IL-6 concentrations in obese persons with and without sleep apnea could be
explained by differences in fat distribution.
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