0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Chronic Systemic Inflammation in Overweight and Obese Adults

Bruce R. Bistrian, MD, PhD; Lalita Khaodhiar, MD
JAMA. 2000;283(17):2235-2236. doi:10.1001/jama.283.17.2235.
Text Size: A A A
Published online

Extract

To the Editor: Dr Visser and colleagues1 found that obesity is associated with elevated levels of CRP and hypothesized that this is related to increased IL-6 production by excess adipose tissue.

We reported clinical data in 24 morbidly obese patients being evaluated for gastric bypass surgery that are consistent with their findings.2 More than half of these patients had erythrocyte sedimentation rates (ESRs) exceeding the upper limit of normal, with levels more than twice normal for the 3 most obese individuals (greater than 275% of desirable body weight). White blood cell counts were normal, hemoglobin values were all greater than 120 g/L, and none of the patients had evidence of an inflammatory disorder. The ESR is a nonspecific indicator of a systemic inflammatory response. The much higher prevalence of elevated levels of ESR in our sample compared with only 6.7% of the population with clinically raised levels of CRP in the study of Visser et al presumably reflects the much higher prevalence of obesity in our sample. It is interesting to speculate that a common consequence of systemic inflammation is the development of anorexia.3

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 37

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();