In Reply: Drs Fernandez and Lesser are concerned
about our inclusion criteria that allowed patients to use concomitant rheumatoid
arthritis drugs (eg, glucocorticoids and methotrexate). However, these therapies
are included in the standard of care for the treatment of rheumatoid arthritis,
and we found that neither glucocorticoid use nor age significantly modified
the effects of celecoxib or naproxen on the upper GI tract mucosa. For patients
younger than 65 years, the incidence of gastroduodenal ulceration with naproxen
was 27% in glucocorticoid users vs 26% in nonusers; in patients aged 65 years
or older, the incidence was 36% in glucocorticoid users and 21% in nonusers.
These data indicate that the susceptibility for NSAID-induced upper GI tract
ulceration is not isolated to a selected subgroup of "at-risk" patients and
the clinical benefit of celecoxib appears to extend to all patients similar
to those studied.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.