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Letters |

Bisphosphonate Therapy and Vascular Calcification—Reply

Steven T. Harris, MD
JAMA. 2000;283(11):1424-1425. doi:10.1001/jama.283.11.1421.
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In Reply: Serious events reported in this study were defined in accordance with regulatory guidelines.1 As noted in Table 3 of our article, the overall incidence of serious adverse events reported was similar between the placebo (27%) and 5-mg risedronate (29%) groups.

We performed a safety analysis focusing on major cardiovascular events reported during the study. Based on this analysis, the most common events occurred at similar incidences between treatment groups. Cardiovascular events reported at a cumulative incidence of more than 1% were right heart failure (placebo, 1.6%; risedronate, 1.8%), myocardial infarction (placebo, 1.6%; risedronate, 1.5%), and cerebrovascular accident (placebo, 1.0%; risedronate, 1.4%).


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