In Reply: Dr Davidson and colleagues raise
several issues regarding my editorial addressing the utility of HbA1C in the diagnosis of diabetes mellitus. Davidson et al suggest that
they have a perfect test with their proposed scheme for use of HbA1C (ie, no false-positive or false-negative test results). This would
be a wonderful (albeit unlikely) scenario for any diagnostic test, and some
questions must be asked: (1) compared with which criterion standard? and (2)
using what definition of "normality"—statistical, or more desirable
prospective scientific studies relating HbA1C values to the development
of diabetes complications?
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