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Estrogen-Receptor Status in Breast Cancer—Reply

Steven R. Cummings, MD; Deborah Grady, MD; Dennis Black, PhD; Stephen Eckert, PhD; Katheryn A. Krueger, MD; Thomas Nickélsen, MD, PhD; Joan E. Glusman, MD; Trevor J. Powles, PhD; Jane A. Cauley, DrPH, FRCP; Larry Norton, MD; Nina H. Bjarnason, MD; Monica Morrow, MD; V. Craig Jordan, PhD, DSc; Marc E. Lippman, MD; Alberto Costa, MD
JAMA. 2000;283(3):338-339. doi:10-1001/pubs.JAMA-ISSN-0098-7484-283-3-jac90010.
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In Reply: The ER status of breast cancer was determined based on clinical reports from the numerous sites that participated in this international study; it was not feasible to mandate a single method. Variability in the assessment of ER status might have led our study to underestimate the differential effect of raloxifene on ER-positive and ER-negative cancer; however, we found that these effects of raloxifene on risk of ER-positive and ER-negative cancer were extremely different.


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