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Letters | August 18, 1999

Myocardial Infarction Associated With Ovarian Hyperstimulation Syndrome

Michael Ludwig, MD; R. Tölg, MD; G. Richardt, MD; H. A. Katus, MD, PhD; K. Diedrich, MD, PhD

JAMA. 1999;282(7):632-633. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-7-jbk0818.

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To the Editor: Ovarian hyperstimulation syndrome is one of the most severe complications following controlled ovarian stimulation. Fluid redistributes from intravascular to extravascular spaces (ie, the abdominal or pleural cavity) leading to ascites and pleural effusions. Most patients can be treated successfully with intravascular fluids and thrombosis prophylaxis. However, complications such as thrombosis and even death have been reported.¹ We report the first case, to our knowledge, of a patient with myocardial infarction after ovarian hyperstimulation syndrome.

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Figure 1. 12-Lead Electrocardiogram at Admission

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ST-segment elevations in the chest leads V₃ to V₆ are due to acute anterior myocardial infarction.

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Figure 2. Coronary Angiogram After Myocardial Infarction

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Top, Thrombus in the proximal left anterior descending artery (arrow 1) and total distal obstruction of the vessel (arrow 2). Bottom, Left ventricular angiogram has an akinetic zone of the anterior and apical myocardial wall (arrows). All projections are in right anterior oblique 30° view.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Ludwig M, Tölg RR, Richardt GG, Katus HA, Diedrich KK. Myocardial Infarction Associated With Ovarian Hyperstimulation Syndrome. JAMA. 1999;282(7):632-633. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-7-jbk0818.

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Figure 1. 12-Lead Electrocardiogram at Admission

Figure 2. Coronary Angiogram After Myocardial Infarction

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