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Letters | July 7, 1999

Inappropriate Secretion of Natriuretic Peptides in a Patient With a Cerebral Tumor

Michael Walter, MD; Elmar Berendes, MD; Alexander Claviez, MD; Meinolf Suttorp, MD

JAMA. 1999;282(1):27-28. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-1-jbk0707.

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To the Editor: Increased plasma concentrations of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) may occur in myocardial infarction, renal insufficiency, and hypertension.¹ The increased secretion of atrial natriuretic peptides from the heart is probably a physiologic reaction to volume overload but also may be due to other mechanisms. We describe a 10-month-old girl with a cerebral tumor and excessive diuresis and natriuresis, thus fulfilling the diagnosis of a cerebral salt-wasting syndrome, as described by Cort² in the 1950s.

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Figure. Magnetic Resonance Tomography Demonstrating a Solid Suprasellar Middle-Line Brain Tumor (Pilocytic Astrocytoma)

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The tumor (arrows) in a 10-month-old patient.

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Walter M, Berendes E, Claviez A, Suttorp M. Inappropriate Secretion of Natriuretic Peptides in a Patient With a Cerebral Tumor. JAMA. 1999;282(1):27-28. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-1-jbk0707.

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Inappropriate Secretion of Natriuretic Peptides in a Patient With a Cerebral Tumor

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Figure. Magnetic Resonance Tomography Demonstrating a Solid Suprasellar Middle-Line Brain Tumor (Pilocytic Astrocytoma)

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