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Autopsy Rates and Diagnosis

Bakul Sangani, MD; Venkataraman Kalyanaraman, MD; Mukesh Bhargava, MD; Joe H. Dwek, MD
JAMA. 1999;281(23):2181. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-23-jac90005.
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To the Editor: The findings reported by Dr Burton and colleagues1 and the accompanying Editorial2 is a timely reminder to clinicians of the importance of the autopsy as a quality-control tool and the danger of its impending demise.

We reviewed 45 consecutive autopsies completed between January 1, 1995, and December 31, 1995, at a small, general community teaching hospital undertaken by residents in internal medicine as part of a quality assurance and medical education program. There were 3061 medical admissions and 317 medical deaths (10.4%) during the study period. The autopsy rate was 14.2%. The purpose was to categorize the errors, identify opportunities for improvement, and evaluate the impact of do not resuscitate status. Whenever a discrepancy between the clinical diagnosis and autopsy findings was found, the error was classified according to the criteria by Landefeld et al3 as to its contribution to the death of the patient. An error is defined as class I when a major unexpected finding, if diagnosed antemortem, would have led to change in therapy and potentially improved survival. A class II error is defined as a major unexpected finding for which antemortem diagnosis would not have changed management. Whenever a discrepancy between the clinical diagnosis and autopsy findings was found, the cause of error was determined using a format modified from Middleton et al.4

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