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May 26, 1999, Vol 281, No. 20 >

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Letters | May 26, 1999

Low-Dose Hydrocortisone for Chronic Fatigue Syndrome

Theodore C. Friedman, MD, PhD; Abby Adesanya; Russell E. Poland, PhD
JAMA. 1999;281(20):1887-1889. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526.
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To the Editor: Dr McKenzie and colleagues1 continued their thorough studies of hypothalamic-pituitary-adrenal axis dysregulation in patients with CFS and found that treatment with hydrocortisone mildly increased their global wellness scale. However, several comments are in order. First, glucocorticoids often induce a feeling of euphoria.2 Because a control population was not studied, the effect may not be specific to patients with CFS since healthy volunteers may also feel "better" when treated with hydrocortisone.

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