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Letters | February 10, 1999

Further Evidence Linking Late-Onset Alzheimer Disease With Chromosome 12

William K. Scott, PhD; Janet M. Grubber, MSPH; Suzanne M. Abou-Donia; Tony D. Church; Ann M. Saunders, PhD; Allen D. Roses, MD; Margaret A. Pericak-Vance, PhD; P. Michael Conneally, PhD; Gary W. Small, MD; Jonathan L. Haines, PhD

JAMA. 1999;281(6):513-514. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-6-jac80022.

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To the Editor: We previously reported the results of a genomic screen and initial follow-up in 54 multiplex families with late-onset Alzheimer disease (AD),¹ describing linkage to several markers in the centromeric region of chromosome 12. We have since reported linkage to chromosome 12 in an independent sample of Amish families.² Two research groups³^- 4 recently reported additional evidence linking late-onset AD to chromosome 12. We now report our additional follow-up studies in relation to these articles.

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Figure. Maximum 2-Point Affecteds-Only Lod Scores (With 5% Misdiagnosis Correction)

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Lod scores exceeded 1 for 6 markers (indicated with the lod scores above the bars), supporting linkage over a broad region of chromosome 12.

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Scott WK, Grubber JM, Abou-Donia SM, et al. Further Evidence Linking Late-Onset Alzheimer Disease With Chromosome 12. JAMA. 1999;281(6):513-514. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-6-jac80022.

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Further Evidence Linking Late-Onset Alzheimer Disease With Chromosome 12

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