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June 8, 2011, Vol 305, No. 22 >

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Medical News & Perspectives | June 8, 2011

Retinoblastoma Therapy Delivers Power of Chemotherapy With Surgical Precision

M. J. Friedrich
JAMA. 2011;305(22):2276-2278. doi:10.1001/jama.2011.778.
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The past century has seen great strides in the treatment of retinoblastoma, with more than 95% of US patients now being cured of this rare childhood malignancy. Building on this success, ophthalmologists have sought to minimize the adverse effects from radiation and systemic chemotherapy, hoping not only to cure the disease but also to save the eye and preserve vision.

A novel approach to treating a rare childhood malignancy, retinoblastoma, is superselective ophthalmic artery infusion of chemotherapy, which delivers a chemotherapeutic agent directly to the eye while minimizing systemic exposure. It is proving to be a simple and superior technique that not only destroys tumors but also can preserve and even restore vision in some cases.
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A novel approach to treating a rare childhood malignancy, retinoblastoma, is superselective ophthalmic artery infusion of chemotherapy, which delivers a chemotherapeutic agent directly to the eye while minimizing systemic exposure. It is proving to be a simple and superior technique that not only destroys tumors but also can preserve and even restore vision in some cases.

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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