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Letters |

Bevacizumab and Cancer Treatment-Related Mortality—Reply

Shenhong Wu, MD, PhD; Vishal Ranpura, MD; Sanjay Hapani, MD
JAMA. 2011;305(22):2291-2293. doi:10.1001/jama.2011.760.
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In Reply: Dr Yang and colleagues identified a number of errors in our study related to incorrect data extraction. They are right, and a correction appears in this issue. We regret the errors. Overall, the final results and conclusions did not change substantially.

The goal of our study was to provide insight into the risk of FAEs related to chemotherapy associated with a biological agent, in this case bevacizumab. These events are most likely the result of serious adverse effects from the treatment, as shown in our study. We agree with Dr Punt and colleagues that many FAEs could be prevented by better adherence to treatment guidelines and adequate patient care. However, our study, being a meta-analysis, was limited in assessing these issues. The included studies did not contain any information regarding the assessment of the relationship between FAEs and treatment and major protocol violations and monitoring results.


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June 8, 2011
Zu-Yao Yang, MD; Chen Mao, MD; Jin-Ling Tang, MD, PhD
JAMA. 2011;305(22):2291-2293. doi:10.1001/jama.2011.757.
June 8, 2011
Cornelis J. A. Punt, MD, PhD; Linda Mol, MSc; Miriam Koopman, MD, PhD
JAMA. 2011;305(22):2291-2293. doi:10.1001/jama.2011.758.
June 8, 2011
Patricia B. Cerrito, PhD
JAMA. 2011;305(22):2291-2293. doi:10.1001/jama.2011.759.
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