Hope in the Age of Anxiety, by Anthony Scioli and Henry Biller, is a captivating and comprehensive work written with great care and delivered with exceptional devotion. Indeed, it is a book in the grand tradition—original, scholarly, thought-provoking, uplifting, and meticulously well referenced. As the title suggests, the work is sweeping in scope and relevant to everyday life, especially during times of challenge, crisis, and illness. By its nature, hope is universal and transcendent, yet curiously familiar. The book will hold wide appeal for readers faced with any manner of adversity, patients and their families, clinicians, and those intrigued by the topic.