Author Contributions: Dr Tramèr had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Czarnetzki, Lysakowski, Giger, Tramèr.
Acquisition of data: Czarnetzki, Lysakowski, Dumont, Landis, Giger, Tramèr.
Analysis and interpretation of data: Czarnetzki, Elia, Lysakowski, Dumont, Landis, Giger, Dulguerov, Desmeules, Tramèr.
Drafting of the manuscript: Czarnetzki, Elia, Tramèr.
Critical revision of the manuscript for important intellectual content: Czarnetzki, Elia, Lysakowski, Dumont, Landis, Giger, Dulguerov, Desmeules, Tramèr.
Statistical analysis: Elia.
Obtained funding: Czarnetzki, Tramèr.
Administrative, technical, or material support: Czarnetzki, Dumont, Landis, Giger, Tramèr.
Study supervision: Tramèr.
Financial Disclosures: Dr Lysakowski reports having received speaker's honoraria from Organon. Dr Desmeules reports having received speaker's honoraria from AstraZeneca. Dr Tramèr reports serving as a consultant for Sintetica and Acacia and having received speaker's honoraria from Fresenius and ProStrakan.
Funding/Support: This work was supported by the EBCAP Foundation (Evidence-Based Critical Care, Anaesthesia and Pain Treatment) (for the salary of Dr Elia) and institutional funds. Dexamethasone was provided by Mepha, Aesch/Basel, Switzerland.
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: We thank the hospital pharmacy of the University Hospitals of Geneva for randomizing and preparing the study drugs; the nurses from the 3DL ward, Geneva University Hospital, who cared for the children; Béatrice Gil-Wey and Jean-Daniel Junod, both from the Division of Anesthesiology, University Hospitals of Geneva, for their roles as research assistants during the course of this trial; Alain Matthey, MD, from the Division of Clinical Pharmacology and Toxicology, University Hospitals of Geneva, for his help in coordinating pharmacovigilance reports for the Swiss Agency for Therapeutic Products (Swissmedic); and Alain Forster, MD, from the ethical committee of the University Hospitals of Geneva for his help in clarifying ethical aspects of early stopping of the trial. None of these persons received any compensation.