We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

ABCA1 Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease—Reply

Anne Tybjærg-Hansen, MD, DMSc; Børge G. Nordestgaard, MD, DMSc; Ruth Frikke-Schmidt, MD, PhD
JAMA. 2008;300(17):1997-1998. doi:10.1001/jama.2008.540.
Text Size: A A A
Published online


In Reply: The overall objective of our study was to examine whether a lifelong lowering of HDL cholesterol levels, without corresponding higher levels of plasma triglycerides or atherogenic remnant lipoproteins,1 was associated with increased risk of IHD. To test this hypothesis, we used heterozygotes for mutations in ABCA1 associated with low cellular cholesterol efflux, as well as with substantial, lifelong lowering of HDL levels, and showed no increase in risk. These results question the hypothesis of reverse cholesterol transport, an active research field. We agree with Dr Brunham and colleagues that genetic variants in ABCA1 may have effects on atherosclerosis independent of effects on HDL levels.24 However, there are some inaccuracies in their letter.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




November 5, 2008
Liam R. Brunham, MD, PhD; John J. P. Kastelein, MD, PhD; Michael R. Hayden, MD, PhD
JAMA. 2008;300(17):1997-1998. doi:10.1001/jama.2008.539.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

10 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.