Author Contributions: Ms Krab had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Krab, De Goede-Bolder, Aarsen, Pluijm, Lequin, Catsman-Berrevoets, Arts, Kushner, Silva, De Zeeuw, Moll, Elgersma.
Acquisition of data: Krab, De Goede-Bolder, Bouman, Lequin, Moll.
Analysis and interpretation of data: Krab, De Goede-Bolder, Aarsen, Pluijm, Van der Geest, Kushner, Moll, Elgersma.
Drafting of the manuscript: Krab, De Goede-Bolder, Van der Geest, Moll, Elgersma.
Critical revision of the manuscript for important intellectual content: Krab, De Goede-Bolder, Aarsen, Pluijm, Bouman, Lequin, Catsman-Berrevoets, Arts, Kushner, Silva, De Zeeuw, Elgersma.
Statistical analysis: Krab, Pluijm, Van der Geest.
Obtained funding: Krab, De Goede-Bolder, De Zeeuw, Moll, Elgersma.
Administrative, technical, or material support: Krab, De Goede-Bolder, Bouman, Van der Geest.
Study supervision: De Goede-Bolder, Aarsen, Lequin, Catsman-Berrevoets, Arts, Silva, De Zeeuw, Moll, Elgersma.
Financial Disclosures: Drs Kushner and Silva reported being coapplicants on a US patent (No. 11/569,426) “Treating learning deficits with inhibitors of HMG-CoA reductase.” None of the other authors reported a potential, real, or perceived conflict of interest or financial disclosure.
Funding/Support: This trial was funded by the Hersenstichting Nederland, the Sophia Foundation for Medical Research, and the Prinses Beatrix Fonds and by a donation from the Dutch Neurofibromatosis Foundation.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank the patients and their parents for their participation. Also, we thank E. Steyerberg, MD, PhD, Department of Public Health, for fruitful discussions, and J. B. C. De Klerk, MD, Department of General Pediatrics and Clinical Genetics, for laboratory safety monitoring. S. J. P. M. Van Engelen, Department of Pediatric Radiology; S. M. Goorden, MSC, M. Elgersma, BSC, P. Plak, BSC, Department of Neuroscience; and A. C. Gaemers, MA, R. Wierenga, MA, E. Barendse, MA, Department of Pediatric Neurology, helped in collecting the data. We appreciate the support of all other participants of the NF1 clinical workgroup and the NF1 Core (Cognitive Research) Team of the Erasmus MC University Medical Center, Sophia Children's Hospital Rotterdam, the Netherlands. None of the acknowledged participants received any form of compensation for their contributions.