Published Online: November 17, 2013. doi:10.1001/jama.2013.282538.
Study concept and design: Rubertsson, Östlund, Silfverstolpe, Lichtveld, Boomars, Kastberg, Halliwell, Box, Herlitz, Karlsten.
Acquisition of data: Rubertsson, Lindgren, Smekal, Silfverstolpe, Lichtveld, Boomars, Ahlstedt, Skoog, Kastberg, Halliwell, Box.
Analysis and interpretation of data: Rubertsson, Lindgren, Östlund, Silfverstolpe, Boomars, Kastberg, Herlitz, Karlsten.
Drafting of the manuscript: Rubertsson, Lindgren, Östlund, Lichtveld, Halliwell, Herlitz, Karlsten.
Critical revision of the manuscript for important intellectual content: Rubertsson, Lindgren, Smekal, Östlund, Silfverstolpe, Lichtveld, Boomars, Ahlstedt, Skoog, Kastberg, Box, Herlitz, Karlsten.
Statistical analysis: Rubertsson, Östlund.
Obtained funding: Rubertsson.
Administrative, technical, or material support: Rubertsson, Lindgren, Smekal, Östlund, Silfverstolpe, Lichtveld, Boomars, Ahlstedt, Skoog, Kastberg, Halliwell, Box, Herlitz, Karlsten.
Study supervision: Rubertsson, Lindgren, Smekal, Östlund, Silfverstolpe, Lichtveld, Boomars, Ahlstedt, Kastberg, Box, Herlitz, Karlsten.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Rubertsson reports receiving funding for consultation from Physio-Control. No other disclosures were reported.
Funding/Support: This work was supported by institutional grants from Uppsala University and by Physio-Control/Jolife AB.
Role of the Sponsor: Physio-Control/Jolife AB provided the mechanical device used in the study, assisted with training, funded a fee per patient enrolled at each site, and funded the CRO-Uppsala Clinical Research Center. Two persons from Physio-Control/Jolife AB were nonvoting members of the steering committee of the study. Physio-Control/Jolife AB had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation or approval of the manuscript. Before submission the sponsor was allowed to review and comment on the manuscript. The investigators were under no obligation to incorporate any such input. The decision to submit for publication was by the authors and not by the sponsor.
Previous Presentation: An abstract of the study was presented at the European Society of Cardiology annual conference; September 1, 2013; Amsterdam, the Netherlands.
Additional Contributions: We thank the members of the LINC study group: Liselott Rehn, RN, and Tomas Nyman, RN, Region Skåne Prehospital Center, Skåne University Hospital, Lund, Sweden; Wendy Bruins, PhD, and Anja Radstok, RN, Regional Ambulance Service Utrecht, Utrecht, the Netherlands; Helena Puggioli, RN, Västerås Central Hospital, Västerås, Sweden; Anna Lindblad, RN, Gävle Hospital, Gävle, Sweden; Douglas Chamberlain, MD, Institute of Primary Care and Public Health, Cardiff University School of Medicine, Cardiff, Wales; and Fredrik Arnwald and Bjarne Madsen Hardig, RN, PhD, Physio-Control/Jolife AB, Lund, Sweden. We also thank the Scandinavian Society of Anaesthesiology and Intensive Care Medicine research board for performing the interim analysis of the data; all involved EMS personnel, ambulance services, and hospital staff in Uppsala, Gävle, Västerås, and Malmö, Sweden, the Dorset region in England, and Utrecht in the Netherlands; and Uppsala Clinical Research Center for handling the database and monitoring the study.