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Return of Secondary Genomic Findings vs Patient Autonomy:  Implications for Medical Care

Robert Klitzman, MD1,2; Paul S. Appelbaum, MD2; Wendy Chung, MD, PhD3,4
[+] Author Affiliations
1Masters of Bioethics Program, Columbia University, New York, New York
2Division of Law, Ethics, and Psychiatry, Department of Psychiatry, Columbia University, New York, New York
3Department of Pediatrics, Columbia University, New York, New York
4Department of Medicine, Columbia University, New York, New York
JAMA. 2013;310(4):369-370. doi:10.1001/jama.2013.41709.
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In April 2013, the American College of Medical Genetics (ACMG) recommended that clinical laboratories conducting whole genome sequencing (WGS) and whole exome sequencing (WES) for specific clinical indications should also analyze and report any mutations identified from a list of 57 genes considered medically actionable, regardless of whether patients wish to receive the results.1 These recommendations have sparked a heated debate with profound implications for countless physicians and their patients.

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