This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.
This randomized clinical trial compares the effect of vasopressin vs norepinephrine on kidney failure in patients with septic shock.
This narrative review summarizes current evidence about the diagnosis and treatment of polymyalgia rheumatica and giant cell arteritis.
This randomized clinical trial compares the effects of family meetings led by palliative care specialists vs intensive care unit teams on anxiety and depression among families of patients with chronic critical illness.
This cluster randomized trial found that among children undergoing mechanical ventilation for acute respiratory failure, use of a nurse-implemented, goal-directed sedation protocol did not reduce the duration of mechanical ventilation compared with usual care.
This randomized clinical trial compares the effects of high-flow nasal cannula oxygen therapy vs conventional oxygen therapy on risk of reintubation among mechanically ventilated patients at low risk for reintubation.
To determine whether statin therapy can decrease day-28 mortality in patients with VAP, Papazian
and coauthors conducted a randomized, placebo-controlled, double-blind, parallel-group, multicenter
trial in 26 intensive care units in France from January 2010 to March 2013.
Annane and coauthors report the results of the CRISTAL pragmatic randomized trial on the effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients. In an accompanying Editorial, Seymour and Angus discuss making a pragmatic choice for fluid resuscitation.
This randomized clinical trial compares the effects of high-flow conditioned oxygen therapy vs noninvasive ventilation (NIV) on postextubation respiratory failure and reintubation among critically ill adult patients.
This cohort study reports the incidence of and outcomes for patients with acute respiratory distress syndrome treated in intensive care units in 50 countries in 2014.
This clinical trial tested whether noninvasive ventilation delivered via helmet reduced intubation rates among intensive care adult patients with acute respiration distress syndrome compared with ventilation delivered via face mask.
This randomized controlled trial assesses whether acetazolamide reduces mechanical ventilation duration among critically ill patients with chronic obstructive pulmonary disease and metabolic alkalosis.