This study pools patient cohorts from randomized and nonrandomized studies to investigate associations between pembrolizumab therapy and tumor response among patients with advanced melanoma with and without prior ipilimumab therapy.
This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.
Carvajal and coauthors conducted a randomized clinical trial to assess the efficacy of selumetinib, a selective, non–adenosine triphosphate competitive inhibitor of the mitogen-activated protein kinase kinase (MEK) enzymes MEK1 and MEK2, among 120 patients with metastatic uveal melanoma.
This randomized trial compares the effects of induction gemcitabine with vs without erlotinib in patients with locally advanced pancreatic cancer and, among those responsive to treatment, compares the effects of chemotherapy with vs without radiation.
This case series involving children and young adults with cancer whose genomic sequencing results were the basis for clinical case recommendations charaterizes the number of clinically actionable findings and resulting patient outcomes.