This study describes process measures and clinical outcomes associated with use of off-site central monitoring of non–critically ill patients in the Cleveland Clinic health system.
This cluster randomized trial investigated the effects of a quality improvement intervention comprising checklists, goal setting, and clinician follow-up vs routine care on mortality among adults in Brazilian intensive care units.
This Viewpoint advocates for equitiable opportunity for prevention, diagnosis, and treatment of cancer to achieve equivalent outcomes for all US residents.
This Clinical Evidence Synopsis discusses whether oral or parenteral corticosteroids are associated with improved clinical outcomes in patients with acute sinusitis compared to placebo or standard clinical care.
In this follow-up study of a US registry of patients undergoing transcatheter aortic valve replacement, 1-year outcomes included overall mortality of 23.7%, stroke rate of 4.1%, and a composite of death and stroke of 26.0%.
Fonarow and coauthors report on door-to-needle times for tissue plasminogen activator (tPA) administration and clinical outcomes in acute ischemic stroke before and after initiation of a quality improvement initiative. In an accompanying Editorial, Grotta discusses progress in achieving faster treatment with tPA for stroke.
To determine whether treating critically ill patients with severe septic shock with esmolol, a
short-acting β-blocker, to reduce their heart rates, Morelli and coauthors conducted an
open-label, randomized phase 2 study, involving 154 qualifying patients treated at a university
hospital intensive care unit.
To determine the effects of weight loss on patients with knee osteoarthritis, Messier and coauthors conducted a 18-month randomized clinical trial comparing 3 interventions—intensive diet-induced weight loss plus exercise, intensive diet-induced weight loss, and exercise—among 454 overweight and obese older community-dwelling adults.