In a trial involving 30 adult patients with sickle cell phenotype with or without thalassemia, Hsieh and coauthors report that after undergoing nonmyeloablative allogeneic hematopoietic stem cell transplantation from human leukocyte antigen–matched siblings, 26 patients achieved long-term engraftment.
Vora and coauthors investigated whether organ transplantation was the source of rabies virus
exposure in a kidney recipient who died 18 months after transplantation. They then evaluated for and
prevented rabies in other transplant recipients from the same donor. In an Editorial, Kaul discusses
the implications for improving the safety of solid organ transplantation.
In this randomized trial among kidney transplant recipients, a 3-month course of levofloxacin initiated early following transplantation did not prevent BK viruria and was associated with an increased risk of adverse events such as bacterial resistance.
This randomized clinical trial investigated whether fully covered, self-expandable metallic stents are noninferior to plastic stents for achieving stricture resolution in patients with benign biliary strictures and a bile duct diameter ≥6 mm in whom the covered metallic stent would not overlap the cystic duct.
This clinical trial tested whether noninvasive ventilation delivered via helmet reduced intubation rates among intensive care adult patients with acute respiration distress syndrome compared with ventilation delivered via face mask.