This JAMA Clinical Guidelines Synopsis summarizes the UK National Clinical Guideline Centre’s 2015 guideline on transfusion of red blood cells.
This randomized trial determines if longer-storage RBCs are inferior to shorter-storage RBCs for tissue oxygenation as measured by reduction in blood lactate levels and cerebral tissue oxygen saturation among children with severe anemia.
This randomized trial reports that among patients with severe trauma and major bleeding, early administration of plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1:1:2 ratio did not result in significant differences in mortality at 24 hours or at 30 days.
Yawn and coauthors summarize a 2014 evidence-based report on the management of sickle cell disease. In an accompanying Editorial, DeBaun discusses the challenge of creating an evidence-based guideline for sickle cell disease.
Robertson and coauthors and the Epo Severe TBI Trial Investigators report the results of a randomized clinical trial on the effect of erythropoietin administration and transfusion threshold on neurological recovery after traumatic brain injury.
Rohde and coauthors evaluate whether red blood cell (RBC) transfusion thresholds are associated with the risk of infection and whether risk is independent of leukocyte reduction in this meta-analysis of 17 trials.
Sherwood and coauthors conducted a retrospective cohort study of 2 258 711 patient visits in the CathPCI Registry to determine current patterns of blood transfusion among patients undergoing percutaneous coronary intervention (PCI) and the association of transfusion with adverse cardiac outcomes.