This randomized clinical trial compares the effects of hydrocortisone vs placebo on development of septic shock among intensive care patients with severe sepsis who were not in septic shock.
This randomized clinical trial compares the effect of vasopressin vs norepinephrine on kidney failure in patients with septic shock.
This article describes the results of a meta-analysis of criteria used to identify adults with septic shock and the processes by which a critical care task force used the results to revise current septic shock definitions.
This article presents updated definitions of and clinical criteria for diagnosing sepsis and septic shock based on recommendations from an expert task force.
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive care unit patients with suspected infection at higher mortality risk.
This Medical News & Perspectives article discusses new sepsis diagnostic guidelines developed by a joint task force of the Society of Critical Care Medicine and European Society of Intensive Care Medicine.
This narrative review summarizes advances in the diagnosis and treatment of septic shock between 2010-2015.
Kaukonen and coauthors describe changes in mortality from 2000 to 2012 for severe sepsis with and without shock in 101 064 patients in 171 intensive care units in Australia and New Zealand. In an Editorial, Iwashyna and Angus discuss the challenge of determining changes in the epidemiology of severe sepsis and evaluating improvements in quality of care.
To determine whether treating critically ill patients with severe septic shock with esmolol, a
short-acting β-blocker, to reduce their heart rates, Morelli and coauthors conducted an
open-label, randomized phase 2 study, involving 154 qualifying patients treated at a university
hospital intensive care unit.