Kim and coauthors report on the effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest. In an accompanying Editorial, Granger and Becker discuss the use of prehospital and immediate cardiac therapies.
This randomized clinical trial compares the effect of hypothermia with vs without xenon on magnetic resonance imaging–assessed white matter damage in comatose patients who had experienced out-of-hospital cardiac arrest in Finland.
This Rational Clinical Examination examines the accuracy of initial history, physical examination, electrocardiogram, and risk scores combined with the first cardiac-specific troponin for diagnosing acute coronary syndrome in the emergency department.
Pearse and coauthors conducted a randomized trial of 734 high-risk patients undergoing gastrointestinal surgery to evaluate the clinical effectiveness of a perioperative, cardiac output–guided hemodynamic therapy algorithm; an updated systematic review and meta-analysis were also conducted. Bennett-Guerrero comments in an editorial.