This randomized trial reports high rates of sustained virologic response in the first part of a open-label study of ombitasvir, paritaprevir (co-dosed with ritonavir), and dasabuvir with ribavirin for 63 patients with hepatitis C virus genotype 1 and human immunodeficiency virus 1 co-infection.
This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of pharmacological and nonpharmacological interventions for patients with Parkinson disease experiencing fatigue.
This Viewpoint discusses the findings of the Government Accountability Office, revisits the premise of physician self-referral, surveys the relevant statutory and regulatory framework, and explores potential solutions to this vexing and costly challenge
This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.
This Viewpoint proposes strategies US states might use to leverage electronic health data to inform policy making in the wake of Gobeille v Liberty Mutual Insurance Company, the Supreme Court decision barring states from requiring that health plans transmit their data to an all-payers claims database.
This Viewpoint discusses the use of body-fixed sensors to accurately track disease status and the effect of treatment in patients with Parkinson disease.
In a cluster randomized trial conducted in Blantyre, Malawi, MacPherson and coauthors investigated whether offering optional home initiation of HIV care after HIV self-testing might increase demand for antiretroviral therapy initiation, compared with HIV self-testing accompanied by facility-based services only.
This Viewpoint discusses the 4 key elements—clinical governance, management capabilities, clinical performance information transparency, and appropriateness of of financial incentives—of large group practice models to preserve successful physician self-regulation in the employment setting.