This Medical News feature discusses the advances in clinical trial design and implementation that have grown out of the precision medicine approach.
This study pools patient cohorts from randomized and nonrandomized studies to investigate associations between pembrolizumab therapy and tumor response among patients with advanced melanoma with and without prior ipilimumab therapy.
This randomized clinical trial compares the effect of sulindac and erlotinib vs placebo on duodenal adenoma regression among people with familial adenomatous polyposis.
This Medical News & Perspectives article discusses cancer immunotherapy, including its development, current applications, additional uses, and potential adverse effects.
This observational database study using the Surveillance, Epidemiology, and End Results 18 registries reports that among US women diagnosed with invasive breast cancer, the likelihood of diagnosis at an early stage, and survival after stage I diagnosis, varied by race and ethnicity.
Kris and coauthors determine the frequency of oncogenic drivers in patients with lung adenocarcinomas and use the data to select treatments targeting the identified driver(s) and measure survival among 1007 US patients with metastatic lung adenocarcinomas.
Omuro and DeAngelis review the clinical management of malignant gliomas, including genetic and environmental risk factors such as cell phones, diagnostic pitfalls, symptom management, specific antitumor therapy, and common complications.
To analyze whether previously reported improvement in disease-free survival with adjuvant gemcitabine therapy translates into improved overall survival, Oettle and coauthors conducted a multicenter, open-label, phase 3 randomized trial to evaluate the efficacy and toxicity of gemcitabine in patients with pancreatic cancer after complete tumor resection.
Rao and coauthors conducted a review of the literature to summarize evidence regarding the role of axillary interventions (surgical and nonsurgical) in breast cancer treatment and to review the association of these axillary interventions with recurrence of axillary node metastases, mortality, and morbidity outcomes in patients with breast cancer.
To determine if racial disparity in breast cancer survival is primarily attributable to differences in presentation characteristics at diagnosis or subsequent treatment, Silber and coauthors compared 7375 black women with 3 sets of 7375 matched white control patients. Mandelblatt and coauthors provide comment in the related Editorial.