This article describes the results of a meta-analysis of criteria used to identify adults with septic shock and the processes by which a critical care task force used the results to revise current septic shock definitions.
G. Wang and coauthors investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood in 1358 children born in Boston, Massachusetts. In an Editorial, Hanson discusses the importance of the developmental origins of health and disease concept in studies.
This cohort study reports that exposure to maternal gestational diabetes mellitus diagnosed by 26 weeks was associated with risk of autism spectrum disorders in offspring born after 28 weeks.
To determine the effects of secretory phospholipase A2 inhibition with varespladib on cardiovascular outcomes, Nicholls and coauthors randomized 5145 patients within 96 hours of presentation of an acute coronary syndrome to either varspladib (n = 2572) or placebo (n = 2573) for 16 weeks.