This randomized trial reports high rates of sustained virologic response in the first part of a open-label study of ombitasvir, paritaprevir (co-dosed with ritonavir), and dasabuvir with ribavirin for 63 patients with hepatitis C virus genotype 1 and human immunodeficiency virus 1 co-infection.
Omuro and DeAngelis review the clinical management of malignant gliomas, including genetic and environmental risk factors such as cell phones, diagnostic pitfalls, symptom management, specific antitumor therapy, and common complications.
This randomized clinical trial evaluates the effect of autologous hematopoietic stem cell transplantation on sustained disease remission among patients with refractory Crohn disease.
The US Burden of Disease Collaborators used a systematic analysis of descriptive epidemiology of diseases and injuries, their sequelae, and risk factors or clusters of risk factors from 1990 to 2010 to describe the health status of the United States. In an editorial, Fineberg discusses the health of the US population.
This study found that longer donor leukocyte telomere length was associated with increased 5-year survival for patients with severe aplastic anemia who had undergone a hematopoietic cell transplant.
Stanley and coauthors conducted a randomized clinical trial among 50 antiretroviral-treated men and women with human immunodefiency virus infection (HIV) and abdominal fat accumulation to investigate the effect of the growth hormone–releasing hormone analog tesamorelin on visceral adipose tissue and liver fat.