In this Special Communication, Anthony Fauci and colleagues review ecological factors contributing to, mechanisms of, and novel strategies to manage antimicrobial resistance.
This study describes the development and diagnostic accuracy of a host-response RNA signature for distinguishing bacterial from viral infection in febrile children younger than 5 years.
This study describes the development and diagnostic accuracy of a host response RNA signature for distinguishing bacterial from nonbacterial infection in infants aged 60 days or younger.
This statement from the International Antiviral Society–USA updates recommendations for the use of antiretroviral drugs (ARVs) to treat adults with established HIV infection and to prevent HIV infection among persons at risk of infection.
This JAMA Clinical Guidelines Synopsis summarizes the US Preventive Services Task Force’s 2013 recommendation statement on screening for human immunodeficiency virus (HIV) infection.
This prospective study sought to determine the incidence, risk factors, and attributable mortality of ICU-acquired infections in patients admitted with or without sepsis.
This Viewpoint explains the importance of optimized antibiotic use in controlling the increasing rate of illness, mortality, and morbidity resulting from antibiotic-resistant infections.
This Viewpoint discusses Zika virus infection and health system preparedness and urges the World Health Organization to proactively respond to the growing global threat of infection.
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive care unit patients with suspected infection at higher mortality risk.
This article presents updated definitions of and clinical criteria for diagnosing sepsis and septic shock based on recommendations from an expert task force.
This cohort study uses Danish patient registry data to investigate associations between hospital-diagnosed pertussis infections and risk of epilepsy.
This population epidemiology study used neonatal registry data to characterize trends in maternal and neonatal care, and morbidity and mortality of extremely preterm infants between 1993 and 2012.
A cluster-randomized crossover trial found that daily bathing of patients in intensive care units with chlorhexidine did not reduce the incidence of health care–associated infections.
This systematic review summarizes the diagnostic approaches for Clostridium difficile infection and evaluates which therapeutic approaches should be used.
A cross-sectional study of 1-day prevalence surveys conducted in 183 US acute care hospitals in 10 states found that antimicrobial drugs were used was 49.9% of the time and use of broad-spectrum drugs was common.