This Danish cohort study investigates the risks of long-term recurrence and mesh-related complications among patients undergoing incisional hernia repair with open mesh, laparoscopic mesh, and open nonmesh surgical techniques.
This Guide to Statistics article compares pragmatic randomized controlled trials, which focus on important challenges that patients, physicians, and policy makers face in day-to-day life with explanatory trials that seek to test a hypothesis.
This randomized clinical trial compares the effect of a primary care–based management intervention vs usual care on mental health–related quality of life among patients surviving sepsis in the critical care setting.
This JAMA Clinical Guidelines Synopsis summarizes the National Comprehensive Cancer Network’s and European Society of Medical Oncology’s recent recommendations on follow-up imaging in patients in remission from Hodgkin and diffuse large B-cell lymphoma.
This randomized trial investigated whether oral hydration with dilute apple juice followed by preferred fluids was noninferior to administration of electrolyte maintenance solution for treatment of children presenting to the emergency department with mild gastroenteritis and minimal dehydration.
This randomized clinical trial compares the effects of a web-based guided self-help intervention vs enhanced usual care for prevention of major depressive disorder among adults with subthreshold depression.
This JAMA Guide to Statistics and Methods discusses how to interpret the results of clinical trials that are stopped early based on formal, prespecified stopping rules.
This cluster randomized trial investigated the effects of a quality improvement intervention comprising checklists, goal setting, and clinician follow-up vs routine care on mortality among adults in Brazilian intensive care units.
This randomized clinical trial investigated whether fully covered, self-expandable metallic stents are noninferior to plastic stents for achieving stricture resolution in patients with benign biliary strictures and a bile duct diameter ≥6 mm in whom the covered metallic stent would not overlap the cystic duct.
This randomized trial compares the effects of mindfulness-based stress reduction vs cognitive behavioral therapy vs usual treatment for improving symptoms and physical function among adult patients with chronic lower back pain.
This cohort study uses paired inspiratory-expiratory computed tomography images to determine the prevalence and clinical significance of expiratory central airway collapse among current and former smokers.
This Recommendation Statement from the US Preventive Services Task Force recommends screening for depression in the general adult population, including pregnant and postpartum women, with adequate systems in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up.
This systematic review to support the 2016 US Preventive Services Task Force Recommendation Statement on screening for depression summarizes trial evidence about depression screening, treatment, and accuracy of screening instruments in pregnant and postpartum women.
This Guide to Statistics and Methods discusses analyzing repeated measurements using mixed models.
This randomized trial compares the efficacy and safety of lung volume reduction therapy using nitinol coils vs usual care for patients with emphysema.
This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.
This randomized trial assesses the long-term clinical outcomes with intravascular ultrasound–guided drug-eluting stent implantation vs those with angiography-guided implantation in Korean patients with long coronary lesions.
This randomized trial reports that in patients with proliferative diabetic retinopathy, ranibizumab treatment resulted in visual acuity that was noninferior to panretinal photocoagulation treatment at 2-year follow-up.
This randomized trial compares the effects of endovascular revascularization and supervised exercise vs supervised exercise alone on walking distance and quality of life among patients with peripheral artery disease and intermittent claudication.
This study uses follow-up data from a randomized trial comparing open and endoscopic release surgery for carpal tunnel syndrome to compare outcomes 11 to 16 years after surgery.