This Medical Letter review summarizes appropriate alternative antibiotic treatment of sinusitis, bronchitis, and uncomplicated urinary tract infections in the wake of US Food and Drug Administration labeling changes warning of the risks of fluoroquinolones.
This systematic review characterizes associations between 3 aspects of antibiotic therapy (optimal time to antibiotic initiation, initial antibiotic selection, and criteria for the transition from intravenous to oral therapy) and short-term mortality in adults hospitalized with community-acquired pneumonia.
A cross-sectional study of 1-day prevalence surveys conducted in 183 US acute care hospitals in 10 states found that antimicrobial drugs were used was 49.9% of the time and use of broad-spectrum drugs was common.
Pasternak and coauthors investigate if oral fluoroquinolone use is associated with increased risk of retinal detachment among more than 6 million participants in Denmark. In an Editorial, Brett discusses how to glean important information from conflicting findings in observational research and apply them to practice.