Lincoff and coauthors determine whether addition of aleglitazar to standard medical therapy reduces cardiovascular morbidity and mortality among 7226 patients with type 2 diabetes mellitus (T2D) and a recent acute coronary syndrome (ACS).
This randomized clinical trial determines whether diet or exercise improves exercise capacity and quality of life among obese older patients with heart failure with preserved ejection fraction (HFPEF).
A 67-year-old woman with idiopathic pulmonary fibrosis was admitted for new-onset cough with bloody sputum following anorexia and vomiting. She had anemia, 6.5 mg/dL serum creatinine, microscopic hematuria without albuminuria, 1:80 ANA titer, 1:160 perinuclear ANCA titer, and a 63-U myeloperoxidase antibody. How do you interpret the results?
This randomized clinical trial reports that among patients with severe community-acquired pneumonia and high initial inflammatory response, the acute use of methylprednisolone compared with placebo decreased treatment failure.
To determine whether statin therapy can decrease day-28 mortality in patients with VAP, Papazian
and coauthors conducted a randomized, placebo-controlled, double-blind, parallel-group, multicenter
trial in 26 intensive care units in France from January 2010 to March 2013.
Leuchter and coauthors conducted a randomized trial to determine if there is an association between early high-dose recombinant human erythropoietin treatment in preterm infants and biomarkers of encephalopathy of prematurity on magnetic resonance imaging (MRI) at term-equivalent age.
This cohort study compares changes in physical function and pain among obese patients 1 to 3 years after bariatric surgery (Roux-en-Y gastric bypass or laparoscopic adjustable gastric banding).
This genome-wide association study performed among children with acute lymphoblastic leukemia (ALL) found that an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy.
This systematic review summarizes the pathophysiology of acute brain ischemia and infarction and available reperfusion treatments.