This randomized clinical trial compares the effects of micafungin vs placebo on 28-day fungal infection–free survival among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure.
This randomized clinical trial compares the effects of high-flow conditioned oxygen therapy vs noninvasive ventilation (NIV) on postextubation respiratory failure and reintubation among critically ill adult patients.
This Rational Clinical Examination systematic review summarizes studies that evaluated the diagnostic accuracy of tests for predicting fluid responsiveness in hemodynamically unstable adult patients to better identify patients who would benefit from further fluid administration.
This randomized clinical trial compares the effects of early vs delayed initiation of renal replacement therapy on 90-day all-cause mortality among critically ill patients with AKI.
This study used survey and qualitative methods to characterize the frequency of and reasons for discordance in estimates of prognosis of critically ill patients made by physicians and surrogate decision makers.
This cluster randomized trial investigated the effects of a quality improvement intervention comprising checklists, goal setting, and clinician follow-up vs routine care on mortality among adults in Brazilian intensive care units.
This Viewpoint discusses prospects for developing new and effective therapeutic strategies for the treatment of critically ill patients.
This case-control study explores the association between circulating histones and thrombocytopenia in patients in the intensive care unit.
This Viewpoint discusses the importance of preserving cerebral function in critical care settings and the challenges of providing care that promotes recovery of brain function and improved functional outcomes.
This randomized controlled trial assesses whether acetazolamide reduces mechanical ventilation duration among critically ill patients with chronic obstructive pulmonary disease and metabolic alkalosis.
This Viewpoint discusses new challenges and opportunities related to the care of critically ill patients.
This cluster randomized trial found that among children undergoing mechanical ventilation for acute respiratory failure, use of a nurse-implemented, goal-directed sedation protocol did not reduce the duration of mechanical ventilation compared with usual care.
This prospective economic evaluation reports that use of LMW heparin for venous thromboembolism prophylaxis in critically ill patients was more effective than unfractionated heparin, with similar or lower costs.
Amrein and coauthors investigate among 492 patients in Austria with vitamin D deficiency whether a vitamin D3 treatment regimen intended to quickly restore and maintain normal vitamin D status over 6 months is of health benefit for patients who are critically ill.