Tilburt and coauthors report results of a survey of US physicians regarding health care cost-containment strategies and personal responsibility for addressing health care costs. In an Editorial, Emanuel and Steinmetz discuss why physicians must take the lead in controlling health care costs.
This randomized clinical trial explores the use of aspirin vs placebo as an early intervention for preventing acute respiratory distress syndrome (ARDS) in at-risk patients presenting to the emergency department.
To assess the accuracy, reliability, and potential refinement of clinical decision rules in a new cohort of patients with headache, Perry and coauthors conducted a multicenter cohort study among 2131 adults with headache peaking at 1 hour and no neurologic deficits. Newman-Toker and Edlow provide comment in the related Editorial.
This narrative review summarizes published evidence on diagnosis and management of acute aortic syndromes with a focus on the evolving roles of medical therapy vs TEVAR vs a traditional open surgical procedure.
This systematic review analyzes how physicians are educated to deliver high-value, cost-conscious care and the circumstances that influence this learning.
This study uses polling data and published surveys, state and country databases, interview studies, and death certificate studies to review the legal status of euthanasia and physician-assisted suicide and the available data on attitudes and practices in the United States, Canada, and Europe.
This randomized clinical trial compares the effect of vasopressin vs norepinephrine on kidney failure in patients with septic shock.
This randomized trial evaluates whether noninvasive ventilation improves 7-day tracheal reintubation and other outcomes compared with standard oxygen therapy among patients with hypoxemic acute respiratory failure after abdominal surgery.
This randomized clinical trial compares the effects of high-flow conditioned oxygen therapy vs noninvasive ventilation (NIV) on postextubation respiratory failure and reintubation among critically ill adult patients.
This Viewpoint by David Ludwig assesses the lessons learned from US nutrition recommendations to limit fat intake and the continuing increase in obesity and diabetes and discusses the challenges inherent in scientific evidence regarding nutrition.
This randomized trial reports that the addition of metformin to insulin does not improve glycemic control in overweight adolescents with type 1 diabetes and increases incidence of gastrointestinal adverse events.
This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.
This randomized clinical trial compares the effects of high-flow nasal cannula oxygen therapy vs conventional oxygen therapy on risk of reintubation among mechanically ventilated patients at low risk for reintubation.