This randomized clinical trial assesses the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation.
This randomized clinical trial compares the effects of hydrocortisone vs placebo on development of septic shock among intensive care patients with severe sepsis who were not in septic shock.
This randomized clinical trial explores the use of aspirin vs placebo as an early intervention for preventing acute respiratory distress syndrome (ARDS) in at-risk patients presenting to the emergency department.
This randomized clinical trial determined that treatment with creatine monohydrate for at least 5 years did not improve clinical outcomes in patients with early Parkinson disease.
This randomized clinical trial compares the effects of liraglutide vs placebo on time to death and rehospitalization and on time-averaged proportional change in N-terminal pro-B-type natriuretic peptide level among patients with heart failure and reduced left ventricular ejection fraction (LVEF) of 40% or lower.
This randomized trial reports that in patients with proliferative diabetic retinopathy, ranibizumab treatment resulted in visual acuity that was noninferior to panretinal photocoagulation treatment at 2-year follow-up.
To examine the effect of low-dose dopamine or low-dose nesiritide added to diuretic therapy on decongestion and renal function in patients with acute heart failure, Chen and coauthors conducted a randomized clinical trial in 360 patients with heart failure and renal dysfunction in North America.