This randomized trial reports high rates of sustained virologic response in the first part of a open-label study of ombitasvir, paritaprevir (co-dosed with ritonavir), and dasabuvir with ribavirin for 63 patients with hepatitis C virus genotype 1 and human immunodeficiency virus 1 co-infection.
This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of pharmacological and nonpharmacological interventions for patients with Parkinson disease experiencing fatigue.
This JAMA Clinical Guidelines Synopsis summarizes the American Academy of Otolaryngology–Head and Neck Surgery’s 2014 clinical practice guideline on diagnosis and management of tinnitus.
This JAMA Clinical Guidelines Synopsis summarizes the UK National Clinical Guideline Centre’s 2015 guideline on transfusion of red blood cells.
This Viewpoint discusses challenges of developing and implementing clinical practice guidelines.
This Viewpoint describes approaches taken by the Los Angeles Department of Health Services to reduce clinical practice variaton across the system.