This randomized trial reports that in patients with proliferative diabetic retinopathy, ranibizumab treatment resulted in visual acuity that was noninferior to panretinal photocoagulation treatment at 2-year follow-up.
This randomized clinical trial compares the effects of liraglutide vs placebo on time to death and rehospitalization and on time-averaged proportional change in N-terminal pro-B-type natriuretic peptide level among patients with heart failure and reduced left ventricular ejection fraction (LVEF) of 40% or lower.
This randomized clinical trial assesses the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation.
This randomized trial reported that among adults and children aged 12 years or older with poorly controlled asthma, use of a soy isoflavone supplement vs placebo did not result in improved lung function or clinical outcomes.
This prospective economic evaluation reports that use of LMW heparin for venous thromboembolism prophylaxis in critically ill patients was more effective than unfractionated heparin, with similar or lower costs.
To examine the effect of low-dose dopamine or low-dose nesiritide added to diuretic therapy on decongestion and renal function in patients with acute heart failure, Chen and coauthors conducted a randomized clinical trial in 360 patients with heart failure and renal dysfunction in North America.
Boughey and coauthors determine the false-negative rate for sentinel lymph node (SLN) surgery following chemotherapy in 663 women initially presenting with biopsy-proven node-positive breast cancer. In an Editorial, Morrow and Dang discuss false-negative rates and their role in determining whether to use more aggressive therapies.