This Medical Letter review summarizes the PCSK9 inhibitor evolocumab prescribed as an adjunct to statins and diet in the treatment of hypercholesterolemia.
This Viewpoint examines interpretation of the American College of Cardiology/American Heart Association cholesterol guidelines and 3 other recently published cholesterol treatment guidelines.
This 40-year observational study reports that sustained, community-wide programs targeting cardiovascular risk factors and behavior changes to improve a Maine county’s population health were associated with reductions in hospitalization and mortality.
This JAMA Clinical Evidence Synopsis discusses the association of fixed-dose combination therapy (polypill) and a reduced risk for cardiovascular disease (CVD).
This Mendelian randomization study reports that genetic predisposition to elevated low-density lipoprotein cholesterol was associated with presence of aortic valve calcium and incidence of aortic stenosis.
Bardach and coauthors assess the effect of a pay-for-performance (P4P) incentives on quality in 84 electronic health record (EHR)–enabled small practices in New York City in the context of an established quality improvement initiative. In an Editorial, Dolor and Schulman discuss the role of financial incentives within primary care practices.
To investigate genetic risk variants for infantile hypertrophic pyloric stenosis, Feenstra and coauthors searched the genome for genetic associations and then validated findings in 3 independent case-control sample sets that included a total of 2664 cases and 4686 controls.