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  • Tumor Gene Testing May Help Guide Breast Cancer Treatment Decisions

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    JAMA. 2016; 316(16):1637-1637. doi: 10.1001/jama.2016.14764
  • Liquid Biopsy to Evaluate Efficacy of Cancer Therapy

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    JAMA. 2016; 316(9):917-917. doi: 10.1001/jama.2016.12068
  • NCI Launches Large Study of Breast Cancer Genetics in Black Women

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    JAMA. 2016; 316(8):808-808. doi: 10.1001/jama.2016.11180
  • Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer

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    JAMA. 2016; 316(3):300-312. doi: 10.1001/jama.2016.9389

    This cohort study uses Netherlands Cancer Registry data to compare the long-term risk of breast cancer among subfertile women treated with ovarian stimulation and in vitro fertilization (IVF) vs non-IVF treatment between 1980 and 1995.

  • You’ve Got Mail

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    JAMA. 2016; 315(21):2275-2276. doi: 10.1001/jama.2016.1757
  • More Women With Breast Cancer Opt for Bilateral Mastectomy Despite Lack of Survival Benefit

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    JAMA. 2016; 315(20):2154-2156. doi: 10.1001/jama.2016.3584

    This Medical News feature looks at why an increasing number of women with breast cancer are choosing contralateral prophylactic mastectomy, as well as approaches to improve the decision-making process for women considering their surgical options.

  • Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection: A Randomized Clinical Trial

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    JAMA. 2016; 315(18):1956-1965. doi: 10.1001/jama.2016.5257

    This cluster random clinical trial tested the effects of reversing the order in which mammograms were read by a second radiologist on the rates of breast cancer detection among 46 screening centers in England.

  • ERBB2 (HER2) Testing in Breast Cancer

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    JAMA. 2016; 315(12):1280-1281. doi: 10.1001/jama.2015.17463

    Diagnostic mammography revealed 2 masses in the left breast of a 35-year-old woman. Image-guided core biopsies revealed a poorly differentiated invasive ductal adenocarcinoma. Estrogen receptor was strongly positive in 95% of tumor cells, progesterone receptor was positive in less than 5% of tumor cells, and ERBB2 (HER2) by immunohistochemistry was scored at 1+. How do you interpret the test results?

  • Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial

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    JAMA. 2015; 314(24):2632-2640. doi: 10.1001/jama.2015.17291

    This randomized clinical trial evaluates the effects of ovarian suppression using the luteinizing hormone–releasing hormone analogue triptorelin on long-term ovarian function, pregnancies, and disease-free survival among premenopausal women receiving adjuvant breast cancer chemotherapy.

  • Prevention of Premature Menopause and Preservation of Fertility in Young Cancer Survivors: Hopeful Though Modest Long-term Results

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    JAMA. 2015; 314(24):2625-2627. doi: 10.1001/jama.2015.17299
  • Mediterranean Diet With Olive Oil May Reduce Breast Cancer Risk

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    JAMA. 2015; 314(20):2122-2122. doi: 10.1001/jama.2015.15119
  • Red-Brown Plaques and Papules in a Patient With Breast Cancer

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    JAMA. 2015; 314(20):2182-2183. doi: 10.1001/jama.2015.10953

    A 55-year-old woman presented with a generalized erythematous maculopapular rash after receiving breast cancer chemotherapy. She was afebrile and had no constitutional symptoms; laboratory evaluation revealed pancytopenia, and a computed tomography scan showed no metastasis. What would you do next?

  • Tackling Breast Cancers Resistant to Hormone Therapy

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    JAMA. 2015; 314(17):1788-1788. doi: 10.1001/jama.2015.13935
  • Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society

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    JAMA. 2015; 314(15):1599-1614. doi: 10.1001/jama.2015.12783

    This guideline updates the American Cancer Society breast cancer screening recommendations for women at average risk for breast cancer.

  • Benefits and Harms of Breast Cancer Screening: A Systematic Review

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    JAMA. 2015; 314(15):1615-1634. doi: 10.1001/jama.2015.13183

    This systematic review reports that among US women at average risk for breast cancer, mammographic screening is associated with reduction in breast cancer mortality, but the magnitude of the benefits and harms of different screening strategies remains uncertain.

  • Obesity’s Effects on the Extracellular Matrix May Fuel Breast Cancer

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    JAMA. 2015; 314(13):1331-1331. doi: 10.1001/jama.2015.11705
  • Treatment Decision Making and Genetic Testing for Breast Cancer: Mainstreaming Mutations

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    JAMA. 2015; 314(10):997-998. doi: 10.1001/jama.2015.8088

    This Viewpoint discusses the tension between increased availability of genetic testing and the usefulness of test results for clinical decision making in the context of breast cancer.

  • Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer

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    JAMA. 2015; 313(13):1347-1361. doi: 10.1001/jama.2014.5985

    This genetic epidemiology study reports that risk of breast and ovarian cancer among women with BRCA1 and BRCA2 mutations varies by mutation type and location.

  • Diagnostic Concordance Among Pathologists Interpreting Breast Biopsy Specimens

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    JAMA. 2015; 313(11):1122-1132. doi: 10.1001/jama.2015.1405

    Elmore and coauthors quantify the magnitude of diagnostic disagreement among pathologists from 8 US clinical practices compared with a consensus panel reference diagnosis and evaluate associated patient and pathologist characteristics.

  • Expertise vs Evidence in Assessment of Breast Biopsies: An Atypical Science

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    JAMA. 2015; 313(11):1109-1110. doi: 10.1001/jama.2015.1945