This pharmacoepidemiology study uses NHANES data to report trends in dietary supplement use among US adults (between 1999 and 2012).
van Zanten and coauthors found that critically ill patients breathing with the aid of ventilation in intensive care units did not experience improvement in infectious complications when receiving immune-modulating nutrients compared with standard high-protein enteral nutrition.
Leuchter and coauthors conducted a randomized trial to determine if there is an association between early high-dose recombinant human erythropoietin treatment in preterm infants and biomarkers of encephalopathy of prematurity on magnetic resonance imaging (MRI) at term-equivalent age.
This randomized trial reports that among older individuals with age-related macular degeneration supplements containing long-chain fatty acids and/or lutein and zeaxanthin had no effect on cognitive function.
This randomized trial of patients who had no history of migraines compared incidence of migraine attacks between those who used aspirin plus clopidogrel vs aspirin plus placebo for 3 months after undergoing transcatheter atrial septal defect closure.
This systematic review to support the 2016 update of the US Preventive Services Task Force Recommendation Statement on screening for impaired visual acuity in older adults summarizes trial evidence about screening and treatment and evidence about the diagnostic accuracy of screening instruments.
In a double-blind, placebo-controlled, parallel-group, randomized clinical trial with 613 patients, Dysken and coauthors investigated the use of vitamin E (alpha tocopherol), memantine, and a combination to slow progression of mild to moderate Alzheimer disease (AD). In an Editorial, Evans and coauthors discuss the best features in trials of AD therapy and a balance between treatment and prevention.
This randomized clinical trial assesses whether prophylactic early high-dose recombinant human erythropoietin (rhEPO) improves neurodevelopmental outcome for preterm infants at 2 years’ corrected age.