This Clinical Evidence Synopsis summarizes a Cochrane review of clinical trials comparing the effects of long-term colchicine treatment with usual care or placebo on cardiovascular events in patients with hepatobiliary diseases, pericarditis, or other diseases.
This clinical trial tested whether noninvasive ventilation delivered via helmet reduced intubation rates among intensive care adult patients with acute respiration distress syndrome compared with ventilation delivered via face mask.
This randomized clinical trial explores the use of aspirin vs placebo as an early intervention for preventing acute respiratory distress syndrome (ARDS) in at-risk patients presenting to the emergency department.
This Clinical Evidence Synopsis summarizes a Cochrane review on use of methylphenidate for treatment of attention-deficit/hyperactivity disorder in children and adolescents.
This Medical News article discusses the progress and promise of the FDA’s Sentinel Initiative designed to surveille potential drug safety issues by mining claims data.
This Viewpoint discusses how policy makers might develop and implement standardized, validated metrics to track the progress of patient safety improvements.
This randomized controlled trial assesses whether acetazolamide reduces mechanical ventilation duration among critically ill patients with chronic obstructive pulmonary disease and metabolic alkalosis.
This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of immunotherapies for multiple sclerosis.
This randomized trial reports that the addition of metformin to insulin does not improve glycemic control in overweight adolescents with type 1 diabetes and increases incidence of gastrointestinal adverse events.
This cohort study of women given Tdap vaccine during pregnancy evaluates associations between time since prior tetanus-containing vaccinations and acute adverse events in mothers and adverse birth outcomes.
This study uses CMS Hospital Compare data to characterize hospitals penalized financially for preventable adverse events and investigates associations between financial penalties and quality scores.
This open-label randomized trial characterizes reductions in serum potassium levels and adverse events among patients with hyperkalemia and diabetes treated with patiromer, an oral potassium binder.
This Clinical Evidence Synopsis summarizes a recent Cochrane review comparing NSAIDs and other therapies for reducing pain and adverse effects associated with acute gout.
This phase 2 randomized trial reports that spores of nontoxigenic Clostridium difficile strain M3 were well tolerated, appeared to be safe, and reduced recurrence of C difficile infection (CDI) among patients who had previously had CDI treated with metronidazole or vancomycin.
This open-label uncontrolled study of patients with chronic HCV genotype 1 infection and cirrhosis reports high rates of SVR12 in those who received a 12-week oral fixed-dose regimen of daclatasvir, asunaprevir, and beclabuvir, with or without ribavirin.
In this randomized trial among kidney transplant recipients, a 3-month course of levofloxacin initiated early following transplantation did not prevent BK viruria and was associated with an increased risk of adverse events such as bacterial resistance.
This JAMA Clinical Evidence Synopsis discusses the association of fixed-dose combination therapy (polypill) and a reduced risk for cardiovascular disease (CVD).
This open-label, single-group feasibility study among patients with relapsing C difficile infection provides data on adverse events and rates of diarrhea resolution following fecal microbiota transplantation using frozen encapsulated inoculum from unrelated donors.
Ikramuddin and coauthors found that the use of vagal verve block therapy to treat morbidly obese patients proved more effective than a sham device but did not reach statistical superiority and was associated with more adverse effects than the sham device.